Determination of Correlation Times from Selective and Non-Selective Spin-Lattice Relaxation Rates and their Use in Drug-Drug and Drug-Albumin Interaction Studies
نویسندگان
چکیده
Os efeitos da variação da concentração da amostra nos valores de deslocamento químico e nas velocidades de relaxação spin-rede seletiva (R1 ) e não seletiva (R1 ) foram medidos em solução para os três isômeros das guanil hidrazonas derivadas do nitrobenzaldeído (NBGH) puros e com a albumina do soro bovino (BSA). Os resultados foram usados para determinar o tempo de correlação (τc), mostrando que o grau de interação intermolecular droga-droga varia com a posição do grupo nitro no anel aromático e que este grau de associação interfere na interação destas drogas com a BSA. Os resultados sugerem que o grau de interação droga-droga e droga-BSA estão relacionados com a atividade in vitro destas drogas contra o Trypanosoma cruzi.
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